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KMID : 1140120110160010058
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Cancer Prevention Research
2011 Volume.16 No. 1 p.58 ~ p.64
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Antioxidant Enzyme-Enhancing Effects of Jeju Water Containing Vanadium in vivo
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Kim Areum-Daseul
Kang Kyoung-Ah
Zhang Rui
Piao Mei Jing
Kim Suh-Kmann
Jee Young-Heun
Lee Nam-Ho
You Ho-Jin
Ko Kyoung-Soo
Hyun Jin-Won
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Abstract
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Recently, we reported that Jeju water containing vanadium (S3, 26.0±?2.0 μg/l) exhibits an antioxidant effect via the scavenging of reactive oxygen species and by enhancing of antioxidant enzyme activities in vitro. In the present study, we examined the antioxidant effect of S3 with regard to antioxidant enzymes in vivo. C57BL/6 mice were given tap water or S3 for 90 days, and then the liver tissues were analyzed. Compared to tap water, S3 enhanced the activities of superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase-1. S3 also enhanced the level of reduced glutathione, which was determined by high-resolution magic angle spinning nuclear magnetic resonance spectroscopy and by a colorimetric assay. These results suggested that vanadium-containing Jeju water has antioxidant effects via enhancing antioxidant enzyme activities in vivo.
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KEYWORD
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Jeju water, Reactive oxygen species, Antioxidant enzyme
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